Hi guys,
A little update, my IT team and I are still in contact with Sophos support team, I gave Sophos support a log using process monitor and Sophos logs, they are investigate about it.
Last version of “Core Agent” of Sophos (2024.3.2.3.0) seems to improve things, obvusly not if Sophos was disactivated.
For info in my case we didn’t need to completly disable Sophos, we just disabled the “Real-time File scanner”.
One test we made is to exclude the AS installation path, it improve a bit the things too.
Actual exclusions done that seems to be improving are:
- C:\BRAutomation\AS412\AS\TechnologyPackages\mappView\5.24.3\bin\CefSharp.BrowserSubprocess.exe
- C:\BRAutomation\AS412\bin-en\pg.exe
But it version related so if you exclude AS installation path, it should do the same.
I will check with Sophos Support if there is a way, when ticket will be closed to update this post to give ID of the ticket. That could maybe help someone else 
As I leave my actual company Friday, I will check with my collegues how we can share you the infos about this
Regards,
Florent